Cutar cututtukan zuciya, wacce ita ce kan gaba wajen mutuwar cututtuka marasa yaduwa, galibi cuta ce da ke da alaƙa da tsufa.Da yawan shekaru, zuciya a matsayin wata gabar da ke zubar da jini, za ta tsufa, kuma karfinta na shakatawa da natsuwa zai ragu, kuma sannu a hankali ta kasa zubar da jini zuwa ga baki daya, wanda a karshe zai haifar da gazawar zuciya. marasa lafiya kuma suna shafar lafiyar mutane sosai.
Tsufa na zuciya yana da alaƙa da raguwar raunin zuciya (aikin zuciya), wanda zai kasance tare da raguwar yawan furotin da kuma canje-canjen gyaran furotin bayan fassarar.
SS-31 peptide shine mai hana cardiolipin peroxidase mai hanawa da kuma peptide mitochondrial mai niyya.Yana iya inganta aikin ventricle na hagu da mitochondria.SS-31 peptide na iya rage rashin aiki na mitochondrial da lalacewar oxidative a cikin ƙwayoyin cuta na trabecular na ɗan adam.Yana iya hana iHTM da GTM(3) sel daga dorewar damuwa na iskar oxygen da H2O2 ya haifar.
SS-31 wani sinadari ne na mitochondrial da ke niyya na rigakafin tsufa, wanda aka tabbatar yana da tasiri wajen maido da aikin zuciya na tsofaffin beraye.Tetrapeptide na roba ne wanda aka haɗe tare da membrane na ciki na mitochondrial, wanda zai iya inganta aikin mitochondrial, rage samar da nau'in iskar oxygen mai amsawa ROS, rage matakin abubuwan da ke haifar da kumburi kuma galibi haɓaka aikin diastolic na zuciya.
Da fari dai, kwatanta matasan beraye da tsofaffin beraye, masana kimiyya sun gano cewa yawancin sunadaran mitochondrial suna da tasiri musamman ta hanyar tsufa, gami da hanyar watsa siginar mitochondrial, sunadaran da ke da alaƙa da hanyar phosphorylation oxidative wanda ke samar da kuzari, da kuma sunadaran da ke da alaƙa da hanyar watsa siginar SIRT masu alaƙa da makamashi. metabolism a cikin mitochondria.Bugu da ƙari, mahimman sunadaran troponin da tropomyosin, waɗanda ke daidaita ƙanƙanwar zuciya kai tsaye, suma suna shafar tsufa.Waɗannan suna da alaƙa kusa da aikin zuciya.Na biyu, lokacin da aka yi la'akari da tasirin maganin SS-31, masu binciken sun gano cewa yawan furotin na tsofaffin berayen da aka kula da su ba su yi daidai da na matasan kungiyar ba, amma duk sun nuna farfadowar hanyar rashin aiki tare da tsufa. irin su furotin mai yawa na zagayowar tricarboxylic acid, babban hanyar samar da makamashi a cikin jiki, wanda da gaske ya murmure sosai, yana sa tsofaffin beraye suna ƙarami.Wannan yana nufin cewa SS-31 yana da tasiri musamman ga canje-canjen makamashin makamashi wanda ya haifar da tsufa na zuciya.Binciken yawan furotin ya zo ƙarshe, sannan masu bincike sun mayar da hankalinsu ga sauye-sauyen sauye-sauyen furotin bayan fassarar a lokacin tsarin tsufa, kuma musamman sun zaɓi mafi yawan gyare-gyaren bayan fassarar a cikin furotin, wanda ya fi dacewa da zuciya. - acetylation gyara.Ana iya samun canje-canje guda biyu a cikin gyaran acetylation.Na farko, saboda acetylation na furotin na mitochondrial zai karu da shekaru, wanda zai haifar da rashin aiki na mitochondrial, kuma abun ciki na mitochondrial na zuciya yana da girma sosai, don haka dukan zuciya na iya samun babban tarin acetylation yayin da aikin zuciya ya ragu;Na biyu, za a yi asarar al'ada acetylation na takamaiman sharuɗɗa a cikin tsarin tsufa, wanda zai haifar da gazawar yin aiki na al'ada.Masu bincike sun wadatar da peptides acetylated a cikin zuciya (wanda za'a iya fahimta kawai azaman ƙananan raka'a da ake amfani da su don samar da furotin).Har yanzu akwai bambance-bambance a cikin matsayin acetylation na sunadaran zuciya tsakanin ƙungiyar matasa da tsohuwar rukuni, amma ba a bayyane yake kamar yawan furotin ba.Sannan kuma sun kara bincikar wadanne sunadaran da wannan canjin yanayin acetylation zai iya zama na musamman.A ƙarshe, masu binciken sun sake danganta ikon systolic da diastolic na zuciya kuma sun gano wuraren acetylation guda 14 da ke da alaƙa da ikon diastolic na zuciya, kuma dukkansu sun yi mummunan alaƙa.A lokaci guda, an kuma sami wurare guda biyu masu alaƙa da raunin zuciya.Wannan yana nufin cewa canjin kwangila a lokacin tsufa na iya daidaitawa ta yanayin acetylation na furotin na zuciya.
Mu masu sana'a ne na polypeptide a kasar Sin, tare da shekaru masu yawa na kwarewa a cikin samar da polypeptide.Hangzhou Taijia Biotech Co., Ltd. ƙwararren ƙwararren masana'anta ne na polypeptide, wanda zai iya samar da dubun dubatan polypeptide albarkatun ƙasa kuma ana iya keɓance shi gwargwadon buƙatu.Ingancin samfuran polypeptide yana da kyau sosai, kuma tsabta zai iya kaiwa 98%, wanda masu amfani suka gane a duk faɗin duniya. Barka da tuntuɓar mu.
