Peptide wani fili ne na kwayoyin halitta, wanda ya bushe daga amino acid kuma ya ƙunshi carboxyl da amino kungiyoyin.Yana da fili mai amphoteric.Polypeptide wani fili ne da aka samar ta amino acid wanda aka haɗe tare ta hanyar haɗin peptide.Yana da matsakaicin samfur na furotin hydrolysis.An kafa ta ta hanyar bushewa da ƙumburi na 10 ~ 100 amino acid kwayoyin, kuma nauyin kwayoyinsa bai wuce 10000 Da ba.Yana iya shiga cikin wani ɗan ƙaramin abu mai yuwuwa kuma ba a haɗe shi ta hanyar trichloroacetic acid da ammonium sulfate, gami da peptides na bioactive da peptides na roba na wucin gadi.
Magungunan polypeptide suna magana ne akan polypeptides tare da takamaiman tasirin warkewa ta hanyar haɗin sinadarai, sake haɗuwa da kwayoyin halitta da haɓakar dabba da shuka, waɗanda galibi an raba su zuwa polypeptides na endogenous (kamar enkephalin da thymosin) da sauran polypeptides na waje (kamar dafin maciji da sialic acid).Matsakaicin nauyin kwayoyin halitta na magungunan polypeptide yana tsakanin magungunan furotin da magungunan micromolecule, wanda ke da fa'idar magungunan micromolecule da magungunan furotin.Idan aka kwatanta da magungunan micromolecule, magungunan polypeptide suna da babban aikin nazarin halittu da ƙayyadaddun ƙayyadaddun ƙayyadaddun abubuwa.Idan aka kwatanta da kwayoyi masu gina jiki, magungunan polypeptide suna da kwanciyar hankali mafi kyau, ƙananan immunogenicity, babban tsabta da ƙananan farashi.
Polypeptide na iya zama kai tsaye kuma yana shayar da shi ta jiki, kuma saurin saurin yana da sauri, kuma ɗaukar polypeptide yana da fifiko.Bugu da ƙari, peptides ba za su iya ɗaukar kayan abinci kawai ba, amma kuma suna watsa bayanan salula don yin umurni da jijiyoyi.Magungunan polypeptide suna da halaye na babban aiki, babban zaɓi, ƙarancin guba da kusancin manufa, amma a lokaci guda kuma suna da rashin amfani na gajeriyar rabin rayuwa, ƙarancin ƙwayar sel mara kyau da kuma hanyar gudanarwa guda ɗaya.
Bisa la'akari da gazawar magungunan polypeptide, masu bincike sun yi ƙoƙari sosai a kan hanyar inganta peptides don inganta haɓakar ƙwayoyin cuta na polypeptide.Cyclization na peptides daya ne daga cikin hanyoyin da za a inganta peptides, da kuma ci gaban cyclic peptides ya kawo alfijir ga polypeptide kwayoyi.Cyclic peptides suna da fa'ida ga magani saboda kyakkyawan kwanciyar hankali na rayuwa, zaɓi da kusanci, haɓakar membrane cell da wadatar baki.Cyclic peptides suna da ayyukan nazarin halittu irin su anti-cancer, anti-kamuwa da cuta, anti-fungus da anti-virus, kuma suna da matukar alƙawarin kwayoyin kwayoyi.A cikin 'yan shekarun nan, magungunan peptide na cyclic sun jawo hankali sosai, kuma kamfanonin harhada magunguna sun bi yanayin haɓakar magunguna na zamani tare da shimfida hanyoyin maganin peptide na cyclic daya bayan daya.
Dr. Chen Shiyu daga cibiyar nazarin harhada magunguna ta Shanghai, kwalejin kimiyya ta kasar Sin ta gabatar da magungunan peptide na cyclic da aka amince da su daga shekarar 2001 zuwa 2021 a cikin magungunan peptide na cyclic da aka amince da su a cikin magunguna biyu na karshe.A cikin shekaru 20 da suka gabata, akwai nau'ikan magungunan cyclic peptide guda 18 a kasuwa, daga cikinsu akwai adadin peptides na cyclic da ke aiki akan haɗin bangon tantanin halitta da β-1,3- glucanase hari shine mafi girma, tare da nau'ikan 3 kowanne.Magungunan peptide cyclic da aka amince da su sun haɗa da cututtukan cututtuka, endocrin, tsarin narkewa, metabolism, ƙari / rigakafi da tsarin juyayi na tsakiya, daga cikin abin da anti-kamuwa da cuta da endocrine cyclic peptide kwayoyi suna lissafin 66.7%.Dangane da nau'in hawan keke, akwai magungunan peptide da yawa da aka yi amfani da su ta hanyar haɗin gwiwar disulfide da cyclized ta hanyar amide bond, kuma an amince da magunguna 7 da 6 bi da bi.
Lokacin aikawa: Satumba 18-2023